Atrial fibrosis plays an important role in both the initiation and maintenance of atrial fibrillation. Fibrotic remodelling is multifactorial and there are multiple methodologies for incorporating the effects of fibrosis in computational models. We demonstrated that the specific representation of fibrosis in biophysical atrial models has a large effect on rotor dynamics and needs to be carefully considered for patient specific modelling.
Further reading:
[1] Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms
[2] Wavelength and Fibrosis Affect Phase Singularity Locations During Atrial Fibrillation
[3] Variability in pulmonary vein electrophysiology and fibrosis determines arrhythmia susceptibility and dynamics
[4] Reproducibility of Atrial Fibrosis Assessment Using CMR Imaging and an Open Source Platform